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DHICA oxidase is a catalytic step downstream from tyrosinase in the biosynthesis of melanin from tyrosine.
The function of Oculocutaneous albinism type 7 results from mutations in an unknown gene, which maps to band 10q22.2-3 and is inherited as an autosomal recessive trait.
The proteins/gene products (and respective gene) affected in each form of oculocutaneous albinism are as follows Oculocutaneous albinism type 1 results from mutations in the tyrosinase gene, which maps to band 11q14-3 and is inherited as an autosomal recessive trait.
The tyrosinase gene encodes an enzyme that initiates the synthesis of melanin using the substrate tyrosine.
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